Side Effects of Nitric Oxide Supplements

Nitric oxide (NO) supplements are a favorite among bodybuilders. Their capacity to widen blood vessels, improve cell signaling, and regulate organ functioning makes them attractive for muscle enhancement.

While most scientists determine nitric oxide supplements to be safe, potentially adverse effects arise from consuming nitric oxide supplements. You should be aware of the following effects before taking such supplements.

Common Side Effects of Nitric Oxide

Two of the most common side effects related to nitric oxide supplements are headaches and gastrointestinal problems.


The most commonly reported side effect among nitric oxide supplement users was a headache. One consumer described symptoms as being “crazy bad.”

Among the most prevalent ingredients in nitric oxide supplements is arginine. According to Mayo Clinic, arginine commonly triggers headaches, dizziness, and restlessness. Some user olso reported light headed/dizziness after lifting, slight shakes for a while after, and an inability to sleep until the early hours of the morning.

Gastrointestinal Problems & Diarrhea

It appeared the next most common side effects were diarrhea and stomach pains. A bodybuilding forum user noted this:

“For some reason after I took it [a dose of NO supplementation] on an empty stomach as it tells you to, Id get a horrible gashish pain in my side. Id be constipated for a few days, thought I had cancer. I quit taking that stuff and now Im fine, not sure but I know it was from that.”

As mentioned, arginine is usually the most prominent ingredient. Mayo Clinic and WebMD experts state arginine consumption may cause diarrhea, gastrointestinal discomfort, and abdominal pain. High arginine content likely explains why NO supplements create these effects.

Potential Hazards/Risks

While most (if not all) major side effects can be averted through adhering to recommended dosages, there are additional risks and hazards for those with varying health concerns.

Low Blood Pressure

Because NO supplementation enhances blood circulation, this usually leads to a drop in blood pressure. Those with already low blood pressure may want to limit nitric oxide supplementation or avoid its use entirely.

Herpes or Cankers

Some scientists presume arginine consumption aggravates herpes and canker sores. According to WebMD, evidence exists that arginine is necessary for the herpes virus to multiply.

Some users olso noticed how nitric oxide supplement give him “frequent chancre sores (inside mouth),” and it was “Usually very painful.”

Asthma and Allergies

WebMD experts explain arginine creates an allergic reaction and worsens the swelling within the airways. Arginine may also worsen asthma conditions.

Mayo Clinic notes those who are allergic or sensitive to arginine should avoid its consumption. Potential symptoms include rash, itching, and shortness of breath. Those who suspect such allergies should first consult with a health professional.

Nitric Oxide Safe Consumption

NO2 MaxDespite these health concerns, there is a safe approach to consuming nitric oxide supplements. Before you begin, consult with your doctor to ensure proper health. We recommended you to choose Crazy Bulk NO2 Max, a safe and legal pharmaceutical grade formula.

Some experts suggest beginning with a small dosage for 1 week in order to assess tolerance, and then to adjust the dosage accordingly. This technique may minimize side effects and enable you to find the ideal dose to suit your individual needs.

While some side effects from nitric oxide supplement consumption may be inevitable, consumers can avoid risks and other serious health problems by adhering to prescribed nitric oxide amounts and assessing tolerance.

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